Yi Li
University of Michigan
StatisticsCovariateCancerInternal medicineEndocrinologySurgeryPathologyOncologyEconometricsEstimatorChemistryImmunologyDiseasePopulationMathematicsComputer scienceCancer researchCarcinogenesisMedicineBiologyCell biology
978Publications
94H-index
29kCitations
Publications 702
Newest
#1Kejun Zhou (North Sichuan Medical College)
#2Mengyi Xie (North Sichuan Medical College)
Last. Yi Li (University of Electronic Science and Technology of China)H-Index: 94
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Background null Characterized by macrophage infiltration, renal inflammation during septic acute kidney injury (AKI) reveals a ubiquitous human health problem. Unfortunately, effective therapies with limited side effects are still lacking. This study is aiming to elucidate the role of Dimethyl fumarate (DMF) in macrophages against oxidative stress of septic AKI. null Methods null Balb/c mice were gavaged by 50 mg/kg DMF then injected with 10 mg/kg LPS by i.p. We examined LPS-induced renal dysfun...
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#2Xi JinH-Index: 5
Last. Kunjie WangH-Index: 17
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PURPOSE To predict the occurrence of calcium oxalate kidney stones based on clinical and gut microbiota characteristics. METHODS Gut microbiota and clinical data from 180 subjects (120 for training set and 60 for validation) attending the West China Hospital (WCH) were collected between June 2018 and January 2021. Based on the gut microbiota and clinical data from 120 subjects (66 non-kidney stone individuals and 54 kidney stone patients), we evaluated eight machine learning methods to predict t...
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#1Zhe Fei (UCLA: University of California, Los Angeles)
#2Qi Zheng (University of Louisville)H-Index: 7
Last. Yi Li (UM: University of Michigan)H-Index: 94
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With the availability of high-dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients’ survival, along with proper statistical inference....
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#1Jianming XuH-Index: 3
Last. Mei Guan (Peking Union Medical College Hospital)H-Index: 2
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Background null Several clinical studies of vascular endothelial growth factor/vascular endothelial growth factor receptor (VEGF/VEGFR) therapy as a second-line treatment for biliary tract cancer (BTC) have shown modest efficacy. In this study, surufatinib was evaluated as a second-line VEGFR therapy in patients with BTC. null Methods null This was a single-arm, multicenter, open-label phase 2 study conducted in China. The study enrolled eligible patients with BTC, who had received surufatinib m...
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#1Bo Hong (Boston Children's Hospital)
#2Tian Xia (Boston Children's Hospital)
Last. Kai Li (Boston Children's Hospital)H-Index: 20
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ABSTRACT Rhabdomyosarcoma is the most common soft tissue sarcoma in children, and embryonal rhabdomyosarcoma is the most typical type of rhabdomyosarcoma. The heterogeneity, etiology, and origin of embryonal rhabdomyosarcoma remain unknown.After obtaining the gene expression data of every cell in the tumor tissue by single-cell RNA sequencing, we used the Seurat package in R studio for quality control, analysis, and exploration of the data. All cells are divided into tumor cells and non-tumor ce...
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#1Tianhang Zhou (PKU: Peking University)
#2Weiran Chen (PKU: Peking University)
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Abstract null null Objective null Children of parents with mental illness (COPMI) are vulnerable during the COVID-19 pandemic. The study aimed to assess the psychosocial impacts of the pandemic and identify potential factors influencing their mental health. null null null Method null 665 COPMI from six sites including Wuhan in China were enrolled. COPMI's mental health and the impacts of COVID-19 were assessed by an online survey. Univariate and multivariate analyses were performed to examine th...
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#1Suleman S. Hussain (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 5
#2Rahul Majumdar (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
Last. Daniel S. Higginson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 17
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Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and homologous recombination (HR). Typical methods to measure pathway usage include integrated cassette reporter assays or visualization of DNA damage induced nuclear foci. It is now well understood that repair of Cas9-induced breaks also involves NHEJ, Alt-EJ, and HR pathways, providing a new format to measure pathway usage. Here, we have developed a simple ...
1 CitationsSource
#1Melody S. GoodmanH-Index: 23
#2Yi Li (UM: University of Michigan)H-Index: 94
Last. Karen M. Emmons (Harvard University)H-Index: 87
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Behavioral risk factors for cancer tend to cluster within individuals, which can compound risk beyond that associated with the individual risk factors alone. There has been increasing attention paid to the prevalence of multiple risk factors (MRF) for cancer, and to the importance of designing interventions that help individuals reduce their risks across multiple behaviors simultaneously. The purpose of this paper is to develop methodology to identify an optimal linear combination of multiple ri...
4 CitationsSource
#1Kimberly Ann Walters (OSU: Ohio State University)H-Index: 1
#2Yi LiH-Index: 94
Last. Zhaohui ZouH-Index: 11
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Li and Tiwari (2008) recently developed a corrected Z-test statistic for comparing the trends in cancer age-adjusted mortality and incidence rates across overlapping geographic regions, by properly adjusting for the correlation between the slopes of the fitted simple linear regression equations. One of their key assumptions is that the error variances have unknown but common variance. However, since the age-adjusted rates are linear combinations of mortality or incidence counts, arising naturall...
6 CitationsSource
#1Ram C. TiwariH-Index: 23
#2Yi LiH-Index: 94
Last. Zhaohui ZouH-Index: 11
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Providing reliable estimates of the ratios of cancer incidence and mortality rates across geographic regions has been important for the National cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) Program as it profiles cancer risk factors as well decides cancer control planning. A fundamental difficulty, however, arises when such ratios have to be computed to compare the rate of a subregion (e.g., California) with that of a parent region (e.g., the US). Such a comparison i...
8 CitationsSource