Synthesis and evaluation of targeted nanomicelle delivery system with rhein as the hydrophobic end and its synergistic therapy effect on tumor

Traditional nanosized drug delivery systems have the disadvantages of low drug loading and poor targeting. Rhein, one of the active free anthraquinones extracted from rhubarb, has been reported to show anti-cancer activity. In this study, folic acid-polyethylene glycol 2000 -rhein (FA-PEG-RH) conjugate nanomicelles were designed and prepared to increase the drug loading capacity and enhance the nanomicelle targeting ability. The drug loading and...