Clinical Applications of Myelin Plasticity for Remyelinating Therapies in Multiple Sclerosis

Central nervous system demyelination in multiple sclerosis (MS) and subsequent axonal degeneration represent a major cause of clinical morbidity. Learning, salient experiences, and stimulation of neuronal activity induce new myelin formation in rodents, and in animal models of demyelination, remyelination can be enhanced via experience‐ and activity‐dependent mechanisms. Furthermore, preliminary studies in MS patients support the use of...