Ketogenic modification of the liver proteome.

Published on Aug 26, 2021in Nature Reviews Endocrinology28.8
· DOI :10.1038/S41574-021-00560-8
Shimona Starling5
Estimated H-index: 5
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#1Kevin B. Koronowski (UCI: University of California, Irvine)H-Index: 12
#2Carolina Magdalen Greco (UCI: University of California, Irvine)H-Index: 3
Last. Cholsoon Jang (UCI: University of California, Irvine)H-Index: 29
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Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in lysine β-hydroxybutyrylation (Kbhb) of histones, and associates with starvation-responsive genes, effectively coupling ketogenic metabolism with gene expression. The emerging diversity of the lysine acylation landscape prompted us to investigate the full proteomic impact of Kbhb. Global protein Kbhb is induced in a tiss...
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