Local DNA synthesis is critical for DNA repair during oocyte maturation
Abstract
Mammalian oocytes can be very long-lived cells and thereby are very likely to encounter DNA damage during their lifetime. Defective DNA repair may result in oocytes that are developmentally incompetent or give rise to progeny with congenital disorders. During oocyte maturation, damaged DNA is repaired primarily by non-homologous end joining (NHEJ) or homologous recombination (HR). Although these repair pathways have been studied extensively, the...
Paper Details
Title
Local DNA synthesis is critical for DNA repair during oocyte maturation
Published Date
Oct 1, 2021
Journal
Volume
134
Issue
19
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