Journal of Cell Science
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#1Sarah D. Neuman (UW: University of Wisconsin–Madison)H-Index: 6
#2Jeff R Jorgensen (CU: Cornell University)H-Index: 4
Last. Arash Bashirullah (UW: University of Wisconsin–Madison)H-Index: 18
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Membrane contact sites are critical junctures for organelle signaling and communication. Endoplasmic reticulum-plasma membrane (ER-PM) contact sites were the first membrane contact sites to be described; however, the protein composition and molecular function of these sites is still emerging. Here, we leverage yeast and Drosophila model systems to uncover a novel role for the Hobbit (Hob) proteins at ER-PM contact sites. We find that Hobbit localizes to ER-PM contact sites in both yeast cells an...
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#1K. Ehring (WWU: University of Münster)H-Index: 1
#2Dominique Manikowski (WWU: University of Münster)H-Index: 7
Last. Kay Grobe (WWU: University of Münster)H-Index: 28
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The Sonic hedgehog (Shh) pathway controls embryonic development and tissue homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, firmly plasma membrane-associated Shh ligand is released from producing cells to signal to distant target cells and how the resistance-nodulation-division transporter Dispatched 1 (Disp, also known as Disp1) regulates this process. Here, we show that inactivation of Disp in Shh-expressing human cells impairs proteolytic Shh...
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#1Amber B. Ouweneel (Leiden University)H-Index: 4
#2Myrthe E. Reiche (UvA: University of Amsterdam)H-Index: 6
Last. Menno Hoekstra (Leiden University)H-Index: 34
view all 10 authors...
The bone marrow has emerged as a potentially important target in cardiovascular disease as it generates all leukocytes involved in atherogenesis. In the current study, we evaluated whether a change in bone marrow functionality underlies the increased atherosclerosis susceptibility associated with high-density lipoprotein (HDL) deficiency. We found that HDL deficiency in mice due to the genetic lack of hepatocyte-derived apolipoprotein A1 (APOA1) was associated with an increase in the Lin-Sca-1+K...
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#1Katharina S Keuenhof (University of Gothenburg)H-Index: 2
#2Lisa Larsson Berglund (University of Gothenburg)H-Index: 3
Last. Johanna L. Höög (University of Gothenburg)H-Index: 15
view all 7 authors...
When the temperature is increased, the heat shock response is activated to protect the cellular environment. The transcriptomics and proteomics of this process are intensively studied, while information about how the cell responds structurally to heat stress is mostly lacking. Here, Saccharomyces cerevisiae were subjected to a mild continuous heat shock (38°C) and intermittently cryo-immobilized for electron microscopy. Through measuring changes in all distinguishable organelle numbers, sizes, a...
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#1Stéphanie Cottier (University of Fribourg)H-Index: 7
#2Roger Schneiter (University of Fribourg)H-Index: 42
Lipid droplets (LDs) are globular intracellular structures dedicated to the storage of neutral lipids. They are closely associated with the endoplasmic reticulum (ER) and are delineated by a monolayer of phospholipids that is continuous with the cytoplasmic leaflet of the ER membrane. LDs contain a specific set of proteins, but how these proteins are targeted to the LD surface is not fully understood. Here we devised a yeast mating-based microscopic readout to monitor the transfer of LD proteins...
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#1Alexander P. Mela (UGA: University of Georgia)H-Index: 2
#2Michelle Momany (UGA: University of Georgia)H-Index: 31
Septins colocalize with membrane sterol-rich regions and facilitate recruitment of cell wall synthases during wall remodeling. We show that null mutants missing an Aspergillus nidulans core septin present in hexamers and octamers (ΔaspAcdc11, ΔaspBcdc3 , or ΔaspCcdc12 ) are sensitive to multiple cell wall-disturbing agents that activate the cell wall integrity MAPK pathway. The null mutant missing the octamer-exclusive core septin (ΔaspDcdc10 ) showed similar sensitivity, but only to a single ce...
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#1Savannah West (The University of Texas Health Science Center at Houston)H-Index: 2
#2Goutham Kodakandla (Rowan University)
Last. Askar M. Akimzhanov (The University of Texas Health Science Center at Houston)H-Index: 9
view all 7 authors...
Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated Ca2+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized STIM1 Ca2+ sensor. Upon ER Ca2+ store depletion, Orai1 and STIM1 form complexes at ER-PM junctions, leading to the formation of activated CRAC channels. Although the importance of ...
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#1Yuan Gao (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Juan Xiong (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Wei-Ke Ji (HUST: Huazhong University of Science and Technology)H-Index: 6
view all 4 authors...
Membrane contact sites (MCSs) between endoplasmic reticulum (ER) and late endosomes/lysosomes (LE/lys) are emerging as critical hubs for diverse cellular events, and changes in their extents are linked to severe neurological diseases. While recent studies show that synaptotagmin-like mitochondrial-lipid-binding (SMP) domain-containing protein PDZD8 may mediate the ER-LE/lys MCSs, the cellular functions of PDZD8 remain largely elusive. Here we attempt to investigate lipid transfer activities of P...
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#1Kirill Ukhanov (UF: University of Florida)H-Index: 11
#2Cedric Uytingco (UF: University of Florida)H-Index: 8
Last. Jeffrey R. Martens (UF: University of Florida)H-Index: 44
view all 6 authors...
The lipid composition of the primary cilia membrane is emerging as a critical regulator of cilia formation, maintenance, and function. Here, we show that conditional deletion of the phosphoinositide 5'-phosphatase gene, Inpp5e, causative of Joubert syndrome in terminally developed mouse olfactory sensory neurons (OSNs) led to a dramatic remodeling of ciliary phospholipids that was accompanied by marked elongation of cilia. PI(4,5)P2 normally restricted to the proximal segment redistributed to th...
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#1Nicolò Ilacqua (Université Laval)H-Index: 1
#2Irene Anastasia (Université Laval)H-Index: 2
Last. Luca Pellegrini (Université Laval)H-Index: 26
view all 8 authors...
Hepatic lipid homeostasis depends on intracellular pathways that respire fatty acid in peroxisomes and mitochondria, and on systemic pathways that secrete fatty acid into the bloodstream, either free or condensed in very-low-density lipoprotein (VLDL) triglycerides. These systemic and intracellular pathways are interdependent, but it is unclear whether and how they integrate into a single cellular circuit. Here, we report that mouse liver wrappER, a distinct endoplasmic reticulum (ER) compartmen...
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