Journal of Cell Science
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#1Savannah J West (University of Texas Health Science Center at Houston)H-Index: 1
#1Savannah J. West (University of Texas Health Science Center at Houston)H-Index: 3
Last. Askar M. Akimzhanov (University of Texas Health Science Center at Houston)H-Index: 9
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Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated Ca2+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized STIM1 Ca2+ sensor. Upon ER Ca2+ store depletion, Orai1 and STIM1 form complexes at ER-PM junctions, leading to the formation of activated CRAC channels. Although the importance of ...
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#1Marius Musielak (University of Osnabrück)H-Index: 1
#2Carolin Sterk (University of Osnabrück)H-Index: 1
Last. Jürgen J. Heinisch (University of Osnabrück)H-Index: 39
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Rho5 is the yeast homolog of the human small GTPase Rac1. We characterized the genes encoding Rho5 and the subunits of its dimeric activating GEF, Dck1 and Lmo1, in the yeast Kluyveromyces lactis. Rapid translocation of the three GFP-tagged components to mitochondria upon oxidative stress and carbon starvation indicate a similar function of KlRho5 in energy metabolism and mitochondrial dynamics as described for its Saccharomyces cerevisiae homolog. Accordingly, Klrho5 deletions are hyper-resista...
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#1Kiril Tishinov (University of Basel)H-Index: 5
#2Anne Spang (University of Basel)H-Index: 48
mRNA decay is a key step in regulating the cellular proteome. Processing bodies (P-bodies) are thought to be sites of mRNA decay and/or storage. P-body units assemble into P-body granules under stress conditions. How this assembly is regulated, however, remains poorly understood. Here, we show that the translational repressor Scd6 and the decapping stimulator Edc3 act partially redundantly in P-body assembly by sequestering the Dcp1/2 decapping complex in the cytoplasm and preventing it from bec...
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#1Oksana Gorshkova (AMU: Aix-Marseille University)
#2Jessica Cappaï (AMU: Aix-Marseille University)H-Index: 1
Last. Arnauld Sergé (AMU: Aix-Marseille University)H-Index: 16
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Leukemic stem cells (LSC) adhere to bone niches by adhesion molecules. These interactions, deeply reorganized in tumors, contribute to LSC resistance and leukemia relapse. However, LSC adhesion mechanisms and potential therapeutic disruption using blocking antibodies remain largely unknown. Junctional adhesion molecule JAM-C over-expression by LSC correlates with increased leukemia severity, constituting a putative therapeutic target. Here, we took advantage of nanoscopy ability to detect single...
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#1Fangyuan Zhou (Georgia Institute of Technology)H-Index: 3
#2Fang Zhang (Georgia Institute of Technology)H-Index: 4
Last. Cheng Zhu (Georgia Institute of Technology)H-Index: 61
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Selectins and integrins are key players of the adhesion and signaling cascade that recruits leukocytes to inflamed tissues. Selectin binding induces β2-integrin binding to slow rolling. A micropipette was used to characterize neutrophil adhesion to E-selectin and intercellular adhesion molecule (ICAM)-1 at room temperature. The time-dependent adhesion frequency displayed two-stage kinetics with an E-selectin-mediated fast increase to a low plateau followed by a slow increase to a high plateau me...
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#1Jenna L Wingfield (UGA: University of Georgia)H-Index: 5
#2Betlehem Mekonnen (UGA: University of Georgia)
Last. Karl F. Lechtreck (UGA: University of Georgia)H-Index: 14
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Flagellar assembly depends on intraflagellar transport (IFT), a bidirectional motility of protein carriers, the IFT trains. The trains are periodic assemblies of IFT-A and IFT-B subcomplexes and the motors kinesin-2 and IFT dynein. At the tip, anterograde trains are remodeled for retrograde IFT, a process that in Chlamydomonas involves kinesin-2 release and train fragmentation. However, the degree of train disassembly at the tip remains unknown. Two-color imaging of fluorescent protein-tagged IF...
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Mammalian oocytes can be very long-lived cells and thereby very likely to encounter DNA damage during their lifetime. Defective DNA repair may result in oocytes that are developmentally incompetent or give rise to progeny with congenital disorders. During oocyte maturation, damaged DNA is repaired primarily by non-homologous end joining (NHEJ) or homologous recombination (HR). Although these repair pathways have been studied extensively, the associated DNA synthesis is poorly characterized. Usin...
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#1Xueting Gao (Tongji University)H-Index: 1
#2Shuai Yu (Tongji University)H-Index: 1
Last. Liang Xu (Tongji University)H-Index: 9
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Emerging evidence has demonstrated that nucleoporins (Nups) play a pivotal role in cell-type-specific gene regulation, but how they control the expression and activity of ion channel genes in the heart remains unclear. Nup50, which is localized in the nucleus of cardiomyocytes, selectively induced an increase in the transcription and translation of Kcna4. The Kcna4 gene encodes a K+ voltage gated channel of shaker-related subfamily member 4 and is essential for regulating the action potential in...
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#1Dipanjana Ghosh (Indian Institute of Science Education and Research, Bhopal)H-Index: 1
#2Ankita Dutta (Indian Institute of Science Education and Research, Bhopal)
Last. Sunando Datta (Indian Institute of Science Education and Research, Bhopal)H-Index: 14
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Collective cell migration (CCM), where cell-cell integrity remained preserved during the movement, plays an important role in the progression of cancer. However, studies describing CCM in cancer progression are majorly focused on the effect of extracellular tissue components on moving cell plasticity. The molecular and cellular mechanisms of CCM during cancer progression remained poorly explored. Here we report that proteolipid protein 2 (PLP2), a colonic epithelium enriched transmembrane protei...
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#1Bhuminder Singh (VUMC: Vanderbilt University Medical Center)H-Index: 10
#2Galina BogatchevaH-Index: 6
Last. Robert J. Coffey (VUMC: Vanderbilt University Medical Center)H-Index: 115
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In polarized MDCK cells, disruption of the tyrosine-based YXXΦ basolateral trafficking motif (Y156A) in the EGFR ligand, epiregulin (EREG), results in its apical mistrafficking and transformation in vivo. However, mechanism(s) underlying these dramatic effects are unknown. Using a doxycycline-inducible system in 3D Matrigel cultures, we now show induction of Y156A EREG in fully formed MDCK cysts results in direct and complete delivery of mutant EREG to the apical cell surface. Within three days ...
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