Original paper
RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
Abstract
The activity of Rho family GTPase protein, RAC1, which plays important normal physiological functions, is dysregulated in multiple cancers. RAC1 is expressed in both estrogen receptor alpha (ER)-positive and ER-negative breast cancer (BC) cells. However, ER-positive BC is more sensitive to RAC1 inhibition. We have determined that reducing RAC1 activity, using siRNA or EHT 1864 (a small molecule Rac inhibitor), leads to rapid ER protein...
Paper Details
Title
RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
Published Date
Aug 9, 2021
Journal
Volume
40
Issue
40
Pages
5950 - 5962
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Notes
History