Original paper

NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer

Volume: 40, Issue: 41, Pages: 5993 - 6006
Published: Aug 12, 2021
Abstract
N-myc downstream-regulated gene 1 (NDRG1) is a key regulator that interacts with many classic tumor signaling pathways, including some molecules downstream of the epidermal growth factor receptor (EGFR). However, whether NDRG1 is involved in the mechanism of resistance to cetuximab (CTX), the first monoclonal antibody targeting the EGFR has not been reported. Here, we found that NDRG1 enhanced the sensitivity of CTX in colorectal cancer (CRC)...
Paper Details
Title
NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer
Published Date
Aug 12, 2021
Journal
Volume
40
Issue
41
Pages
5993 - 6006
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