Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes

Background Patients with germline/somatic BRCA1/BRCA2 mutations (g/s BRCA1/2 ) comprise a distinct biologic subgroup of pancreas ductal adenocarcinoma (PDAC). Methods Institutional databases were queried to identify patients who had PDAC with g/s BRCA1/2 . Demographics, clinicopathologic details, genomic data (annotation s BRCA1/2 according to a precision oncology knowledge base for somatic mutations), zygosity, and outcomes were abstracted....