Internal medicine

Macular degeneration

Diabetes mellitus

Ophthalmology

Pharmacodynamics

Pharmacokinetics

Endocrinology

Surgery

Intensive care medicine

Physical therapy

Randomized controlled trial

Diabetic retinopathy

Clinical Practice

Diabetic macular edema

Clinical trial

Medicine

The treatment and outcomes of diabetic macular oedema (DMO) have improved with the introduction of intravitreal injections. However, real-world data reveal that the burden of DMO treatment causes large gaps in outcomes between randomized clinical trials and daily clinical practice. Long-lasting intravitreal drugs and devices for DMO might reduce this disparity by achieving optimal treatment due to more feasible injection regimens. In this manuscript, we cover pharmacodynamics, preliminary results from clinical trials, and safety behavior about brolucizumab, faricimab, conbercept, KSI-301, and port-delivery system WR42221. These treatments might present the first step to control the global epidemic of diabetic eye disease in real life.

Next-generation anti-VEGF agents for diabetic macular oedema