The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage
Volume: 118, Issue: 32
Published: Aug 5, 2021
Abstract
Vertebrate mammals express a protein called Ki-67 which is most widely known as a clinically useful marker of highly proliferative cells. Previous studies of human cells indicated that acute depletion of Ki-67 can elicit a delay at the G1/S boundary of the cell cycle, dependent on induction of the checkpoint protein p21. Consistent with those observations, we show here that acute Ki-67 depletion causes hallmarks of DNA damage, and the damage...
Paper Details
Title
The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage
Published Date
Aug 5, 2021
Volume
118
Issue
32
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