CD36 pumps fat to defang killer T cells in tumors
Abstract
The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor...
Paper Details
Title
CD36 pumps fat to defang killer T cells in tumors
Published Date
Aug 1, 2021
Journal
Volume
33
Issue
8
Pages
1509 - 1511
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Notes
History