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The Journal of Urology

You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma II (MP48)1 Sep 2021MP48-19 STAGE AND CANCER SPECIFIC MORTALITY DIFFERS WITHIN SPECIFIC ASIAN ETHNIC GROUPS IN UPPER TRACT UROTHELIAL CARCINOMA Claudia Collà Ruvolo, Christoph Würnschimmel, Luigi Nocera, Mike Wenzel, Roberto La Rocca, Giuseppe Celentano, Marco Capece, Francesco Trama, Gianluigi Califano, Zhe Tian, Shahrokh F. Shariat, Fred Saad, Massimiliano Creta, Ciro Imbimbo, Nicola Longo, Paolo Verze, Alberto Briganti, Vincenzo Mirone, and Pierre I. Karakiewicz Claudia Collà RuvoloClaudia Collà Ruvolo More articles by this author , Christoph WürnschimmelChristoph Würnschimmel More articles by this author , Luigi NoceraLuigi Nocera More articles by this author , Mike WenzelMike Wenzel More articles by this author , Roberto La RoccaRoberto La Rocca More articles by this author , Giuseppe CelentanoGiuseppe Celentano More articles by this author , Marco CapeceMarco Capece More articles by this author , Francesco TramaFrancesco Trama More articles by this author , Gianluigi CalifanoGianluigi Califano More articles by this author , Zhe TianZhe Tian More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat More articles by this author , Fred SaadFred Saad More articles by this author , Massimiliano CretaMassimiliano Creta More articles by this author , Ciro ImbimboCiro Imbimbo More articles by this author , Nicola LongoNicola Longo More articles by this author , Paolo VerzePaolo Verze More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , and Pierre I. KarakiewiczPierre I. Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002074.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: No previous studies examined the effect of specific Asian ethnic subgroups on stage at presentation and cancer-specific mortality (CSM) in non-metastatic upper tract urothelial carcinoma (UTUC) patients treated with radical nephroureterectomy (RNU). We tested this concept and hypothesized that differences may exist. METHODS: We relied on Surveillance, Epidemiology and End Results database, from 2004 to 2016. Kaplan Meier plots and multivariable Cox regression models were used. RESULTS: Of 584 UTUC patients, 173 (29.6%) were Chinese vs 130 (22.3%) Japanese vs 68 (11.6%) Korean vs 64 (11.0%) Filipino vs 40 (6.8%) Vietnamese vs 109 (18.7%) other. Vietnamese and Chinese patients exhibited the highest rates of T4N0M0 and/or T1-4N1-2M0 (25.0% and 18.5%, respectively) relative to other Asian ethnic subgroups. In Kaplan Meier plots, Vietnamese patients exhibited the highest CSM rate. In multivariable models, Vietnamese ethnicity also independently predicted highest CSM (Hazard ratio [HR] 2.15, p=0.02). All other Asian ethnic subgroups exhibited similar CSM patterns. CONCLUSIONS: Vietnamese and Chinese patients are at a stage disadvantage at UTUC diagnosis, relative to all other Asian ethnicities. After adjustment for stage, only Vietnamese patients demonstrated a survival disadvantage relative to all other Asian ethnic subgroups. In consequence, it appears that Vietnamese patients not only present at higher UTUC stage, but additionally appear to harbor UTUC that progresses at faster rate than in other Asian ethnic subgroups. Source of Funding: Not applicable © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e872-e873 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Claudia Collà Ruvolo More articles by this author Christoph Würnschimmel More articles by this author Luigi Nocera More articles by this author Mike Wenzel More articles by this author Roberto La Rocca More articles by this author Giuseppe Celentano More articles by this author Marco Capece More articles by this author Francesco Trama More articles by this author Gianluigi Califano More articles by this author Zhe Tian More articles by this author Shahrokh F. Shariat More articles by this author Fred Saad More articles by this author Massimiliano Creta More articles by this author Ciro Imbimbo More articles by this author Nicola Longo More articles by this author Paolo Verze More articles by this author Alberto Briganti More articles by this author Vincenzo Mirone More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement Loading ...

MP48-19 STAGE AND CANCER SPECIFIC MORTALITY DIFFERS WITHIN SPECIFIC ASIAN ETHNIC GROUPS IN UPPER TRACT UROTHELIAL CARCINOMA