Inhibition of Rev-erbα ameliorates muscular dystrophy
Abstract
Duchene muscular dystrophy leads to progressive muscle structural and functional decline due to chronic degenerative-regenerative cycles. Enhancing the regenerative capacity of dystrophic muscle provides potential therapeutic options. We previously demonstrated that the circadian clock repressor Rev-erbα inhibited myogenesis and Rev-erbα ablation enhanced muscle regeneration. Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx...
Paper Details
Title
Inhibition of Rev-erbα ameliorates muscular dystrophy
Published Date
Sep 1, 2021
Journal
Volume
406
Issue
2
Pages
112766 - 112766
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