Efficacy of high versus conventional dose of ergocalciferol supplementation on serum 25‐hydroxyvitamin D and interleukin‐6 levels among hemodialysis patients with vitamin D deficiency: A multicenter, randomized, controlled study

Long-term dialysis involves a chronic inflammatory state and produces a high prevalence of vitamin D deficiency. A clinical trial was conducted in hemodialysis with serum 25-hydroxyvitamin D (25[OH]D) level <30 ng/ml. The conventional-group (N = 35) and the high-dose group (N = 35) were treated with ergocalciferol according to the K/DOQI guidelines and double dosage of ergocalciferol from the recommendation for 8 weeks, respectively. The main...