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doi.org/10.1161/atvbaha.121.316535

High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1 −/− Mice

..., Henry J. Pownall
58
Arteriosclerosis, Thrombosis, and Vascular Biology8.70
Volume: 41, Issue: 10
Published: Oct 1, 2021
Abstract
Objective: Overall and atherosclerosis-associated mortality is elevated in humans with very high HDL (high-density lipoprotein) cholesterol concentrations. Mice with a deficiency of the HDL receptor, Scarb1 (scavenger receptor class B type 1), are a robust model of this phenotype and exhibit several additional pathologies. We hypothesized that the previously reported high plasma concentration of free cholesterol (FC)-rich HDL in Scarb1-/- mice...
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Paper Details
Title
High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1 −/− Mice
DOI
doi.org/10.1161/atvbaha.121.316535
Published Date
Oct 1, 2021
Journal
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume
41
Issue
10
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