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Original paper

Multicomponent Plasmid Protects Mice From Spontaneous Autoimmune Diabetes

Volume: 71, Issue: 1, Pages: 157 - 169
Published: Aug 13, 2021
Abstract
Type 1 diabetes is an autoimmune disease in which insulin-secreting β-cells are destroyed, leading to a lifelong dependency on exogenous insulin. There are no approved disease-modifying therapies available, and future immunotherapies would need to avoid generalized immune suppression. We developed a novel plasmid expressing preproinsulin2 and a combination of immunomodulatory cytokines (transforming growth factor-β1, interleukin [IL]-10, and...
Paper Details
Title
Multicomponent Plasmid Protects Mice From Spontaneous Autoimmune Diabetes
Published Date
Aug 13, 2021
Journal
Volume
71
Issue
1
Pages
157 - 169
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