SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer
Volume: 6, Issue: 18
Published: Sep 22, 2021
Abstract
BACKGROUNDImmune checkpoint inhibitors (ICIs) fail to demonstrate efficacy in pancreatic cancer. Recently, genomic biomarkers have been associated with response to ICIs: microsatellite instability high (MSI-H) and tumor mutation burden (TMB) > 10 mutations/Mb. Alterations in Switch/Sucrose Nonfermentable (SWI/SNF) chromatin remodeling genes may predispose to improved outcomes with immunotherapy. The current study examined a possible role for...
Paper Details
Title
SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer
Published Date
Sep 22, 2021
Volume
6
Issue
18
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