Original paper
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney
Abstract
In the present study, we tested the hypothesis that there are significant sex differences in angiotensin II (Ang II)-induced hypertension and kidney injury using male and female wildtype (WT) and proximal tubule-specific AT1a receptor knockout mice (PT-Agtr1a−/−). Twelve groups (n=8–12 per group) of adult male and female WT and PT-Agtr1a−/− mice were infused with a pressor dose of Ang II via osmotic minipump for 2 weeks (1.5 mg/kg/day, i.p.) and...
Paper Details
Title
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney
Published Date
Aug 1, 2021
Journal
Volume
135
Issue
15
Pages
1825 - 1843
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Notes
History