Direct oral anticoagulants in patients with nonvalvular atrial fibrillation and extreme body weight

Background Limited clinical data exist describing the use of direct oral anticoagulants (DOACs) in patient with extreme body weight. Thus, the International Society of Thrombosis and Haemostasis (ISTH) recommends avoiding DOACs in patients with weight >120 Kg, and on the contrary, no restrictions exist for underweight patients. Objective To evaluate the effects of extreme body weight on DOAC activity and to compare the clinical outcomes of...