Prognostic impact of somatic mutations on time to first treatment: Results of targeted next‐generation sequencing in 211 patients with early stage chronic lymphocytic leukemia

The clinical course of patients with CLL is highly heterogeneous reflecting an underlying biologic heterogeneity of the disease. In the last decade, whole exome/genome sequencing and targeted next-generation sequencing (NGS) techniques have revealed several genes recurrently mutated in CLL, involving a limited number of pathways, namely microenvironment-dependent signaling through NOTCH (NOTCH1, FBXW7), inflammatory receptors (MYD88),...