Original paper
Loss of PIKfyve drives the spongiform degeneration in prion diseases
Abstract
Brain-matter vacuolation is a defining trait of all prion diseases, yet its cause is unknown. Here, we report that prion infection and prion-mimetic antibodies deplete the phosphoinositide kinase PIKfyve-which controls endolysosomal maturation-from mouse brains, cultured cells, organotypic brain slices, and brains of Creutzfeldt-Jakob disease victims. We found that PIKfyve is acylated by the acyltransferases zDHHC9 and zDHHC21, whose...
Paper Details
Title
Loss of PIKfyve drives the spongiform degeneration in prion diseases
Published Date
Jul 22, 2021
Journal
Volume
13
Issue
9
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Notes
History