Metabolism and Innate Immunity Meet at the Mitochondria

Volume: 9
Published: Jul 27, 2021
Abstract
Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation, including mitochondrial DNA (mtDNA), which are normally shielded from the rest of the cell and extracellular environment and therefore do not elicit detrimental inflammatory cascades. Mitochondrial damage and dysfunction can lead to the cytosolic and extracellular...
Paper Details
Title
Metabolism and Innate Immunity Meet at the Mitochondria
Published Date
Jul 27, 2021
Volume
9
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