Last. Xing-Quan Zhu(Yunnan Agricultural University)H-Index: 38
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Bone marrow is the main hematopoietic organ that produces red blood cells, granulocytes, monocyte/macrophages, megakaryocytes, lymphocytes, and myeloid dendritic cells. Many of these cells play roles in the pathogenesis of Toxocara canis infection, and understanding how infection alters the dynamics of transcription regulation in bone marrow is therefore critical for deciphering the global changes in the dog transcriptional signatures during T. canis infection. In this study, long non-coding RNA...
Last. Wei Cui(Peking Union Medical College)H-Index: 16
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N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes. Accumulating evidence suggests that dysregulation of m6A modification is significantly correlates with tumorigenesis and progression. In this study, we observed an increasing expression and positive correlations of all 24 m6A regulators in esophageal cancer (ESCA) data obtained from the TCGA database. Through expression profiling of these regulators, a prognostic score model containing HNRNPA2B1, ALKBH5 and HNRNPG was ...
#1Marta Sampietro(Centro Nacional de Investigaciones Cardiovasculares)
#2Moreno Zamai(Centro Nacional de Investigaciones Cardiovasculares)H-Index: 19
Last. Valeria R. Caiolfa(Centro Nacional de Investigaciones Cardiovasculares)H-Index: 16
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HS1, the hematopoietic homolog of cortactin, acts as a versatile actin-binding protein in leucocytes. After phosphorylation, it is involved in GTPases and integrins activation, and in BCR, TCR, and CXCR4 downstream signalling. In normal and leukemic B cells, HS1 is a central cytoskeletal interactor and its phosphorylation and expression are prognostic factors in Chronic Lymphocytic Leukaemia (CLL) patients. We here introduce for the first time a super-resolution imaging study on primary CLL cell...
Last. Cheng Li(Ha Tai: Xiamen University)H-Index: 9
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It has been a long-standing challenge to obtain from cell cultures adequate amounts of mouse corneal epithelial cells (mCEC) to perform transplantation surgery. This limitation is attributable to the passage dependent declines in their proliferative activity. We describe here development of a novel 6C medium that contains six different modulators of different signaling pathways, which control proliferative mCEC activity. Its usage shortens the time and effort required to obtain epithelial sheets...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, which is significantly harmful to human health. Recently, the role of N6‐methyladenosine (m6A) RNA methylation in eukaryotic mRNA in the pathogenesis and prognosis of cancer has become increasingly obvious. Moreover, tumor microenvironment plays an important role in the regulation of tumorigenesis. In this research, the clinical data of 374 tumor and 50 normal patients was downloaded from the Cancer Genome Atlas (TCGA). Then...