Original paper
PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models
Abstract
Despite Auger electrons being highly appealing due to their short-range and high linear energy transfer to surrounding tissues, the progress in the field has been limited due to the challenge in delivering a therapeutic dose within the close proximity of cancer cell’s DNA. Here, we demonstrate that the PARP inhibitor 123I-MAPi is a viable agent for the systemic administration and treatment of p53 mutant cancers. Significantly, minimal off-site...
Paper Details
Title
PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models
Published Date
Jul 28, 2021
Journal
Volume
18
Issue
9
Pages
3418 - 3428
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Notes
History