Molecular Pharmaceutics
Papers 5,404
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#1Sean T. Holmes (FSU: Florida State University)H-Index: 10
#2James M. Hook (UNSW: UNSW Sydney)H-Index: 33
Last. Robert W. Schurko (FSU: Florida State University)H-Index: 37
view all 3 authors...
This study uses 35Cl and 14N solid-state NMR (SSNMR) spectroscopy and dispersion-corrected plane-wave density functional theory (DFT) calculations for the structural characterization of chloride salts of nutraceuticals in their bulk and dosage forms. For eight nutraceuticals, we measure the 35Cl EFG tensor parameters of the chloride ions and use plane-wave DFT calculations to elucidate relationships between NMR parameters and molecular-level structure, which provide rapid NMR crystallographic as...
#1Tanushree Ganguly (UCD: University of California, Davis)H-Index: 3
#2Nadine Bauer (UCD: University of California, Davis)H-Index: 7
Last. Julie L. Sutcliffe (UCD: University of California, Davis)H-Index: 27
view all 6 authors...
The incorporation of non-covalent albumin binding moieties (ABMs) into radiotracers results in increased circulation time, leading to a higher uptake in the target tissues such as the tumor, and, in some cases, reduced kidney retention. We previously developed [18F]AlF NOTA-K(ABM)-αvβ6-BP, where αvβ6-BP is a peptide with high affinity for the cell surface receptor integrin αvβ6 that is overexpressed in several cancers, and the ABM is an iodophenyl-based moiety. [18F]AlF NOTA-K(ABM)-αvβ6-BP demon...
#1Asli Celebioglu (CU: Cornell University)H-Index: 32
#2Nancy Wang (CU: Cornell University)
Last. Tamer Uyar (CU: Cornell University)H-Index: 62
view all 5 authors...
Prednisolone is a widely used immunosuppressive and anti-inflammatory drug type that suffers from low aqueous solubility and bioavailability. Due to the inclusion complexation with cyclodextrins (CDs), prednisolone's drawbacks that hinder its potential during the administration can be eliminated effectively. Here, we have early shown the electrospinning of free-standing nanofibrous webs of CD/prednisolone inclusion complexes (ICs) in the absence of a polymer matrix. In this study, hydroxypropyl-...
#1Mahdieh Nemati (TBZMED: Tabriz University of Medical Sciences)H-Index: 2
#2Farhad Bani (TBZMED: Tabriz University of Medical Sciences)H-Index: 8
Last. Huile Gao (SCU: Sichuan University)H-Index: 61
view all 11 authors...
The formation of protein corona (PC) around nanoparticles (NPs) has been reported inside biological conditions. This effect can alter delivery capacity toward the targeted tissues. Here, we synthesized folic acid-modified chitosan NPs (FA-CS NPs) using different concentrations of folic acid (5, 10, and 20%). FA-CS NPs were exposed to plasmas of breast cancer patients and healthy donors to evaluate the possibility of PC formation. We also monitored uptake efficiency in in vitro conditions after i...
#1Xingyu Lu (WIAS: Westlake University)H-Index: 21
#2Mingyue Li (MSD: MSD)H-Index: 11
Last. Yongchao Su (The University of Texas at Austin)H-Index: 32
view all 13 authors...
The introduction of solubilizing additives has historically been an attractive approach to address the ever-growing proportion of poorly water-soluble drug (PWSD) compounds within the modern drug discovery pipeline. Lipid-formulations, and more specifically micelle formulations, have garnered particular interest because of their simplicity, size, scalability, and avoidance of solid-state limitations. Although micelle formulations have been widely utilized, the molecular mechanism of drug solubil...
#1Abbie Dodd (MAHSC: Manchester Academic Health Science Centre)
#2Az Alddien Natfji (University of Reading)H-Index: 4
Last. Lynda K. Harris (MAHSC: Manchester Academic Health Science Centre)H-Index: 23
view all 10 authors...
Here, we evaluated the feasibility of non-prodrug PEG-drug conjugates to decrease the accumulation of drugs within the placental tissues. The results showed that PEG was biocompatible with the human placenta with no alteration of the basal rate of proliferation or apoptosis in term placental explants. No significant changes in the released levels of lactate dehydrogenase and the human chorionic gonadotropin were observed after PEG treatment. The cellular uptake studies revealed that conjugating ...
#1Filip Miljković (AstraZeneca)H-Index: 9
#2Anton Martinsson (AstraZeneca)H-Index: 1
Last. Nigel Greene (AstraZeneca)H-Index: 4
view all 8 authors...
Prior to clinical development, a comprehensive pharmacokinetic characterization of a novel drug is required to understand its exposure at the site of action and elimination. Accordingly, in vitro assays and animal pharmacokinetic studies are regularly employed to predict drug exposure in humans, which is often costly and time-consuming. For this reason, the prediction of human pharmacokinetics at the point of design would be of high value for drug discovery. Therefore, we have established a comp...
#1Rohit Sharma (BARC: Bhabha Atomic Research Centre)H-Index: 6
#2Manoj Kumbhakar (BARC: Bhabha Atomic Research Centre)H-Index: 31
Last. Archana Mukherjee (BARC: Bhabha Atomic Research Centre)H-Index: 12
view all 3 authors...
Human epidermal growth factor receptor 2 (HER2) is overexpressed in breast, gastric, esophageal, ovarian, and endometrial cancer. Combination therapy using trastuzumab and pertuzumab antibodies targeting HER2 has shown better survival outcomes in breast cancer patients. In the quest to understand the synergistic effect observed due to combination therapy, trastuzumab, pertuzumab, and their F(ab')2 fragments were labeled with radioisotope and fluorescent probes. Detailed in vitro studies to under...
#1Manreet Kaur (DMU: De Montfort University)H-Index: 1
#2Vanessa Yardley (University of London)H-Index: 53
Last. Mingzhong Li (DMU: De Montfort University)H-Index: 20
view all 7 authors...
We report the evaluation and prediction of the pharmacokinetic (PK) performance of artemisinin (ART) cocrystal formulations, that is, 1:1 artemisinin/orcinol (ART-ORC) and 2:1 artemisinin/resorcinol (ART2-RES), using in vivo murine animal and physiologically based pharmacokinetic (PBPK) models. The efficacy of the ART cocrystal formulations along with the parent drug ART was tested in mice infected with Plasmodium berghei. When given at the same dose, the ART cocrystal formulation showed a signi...
#1Megha Srinivas (IISc: Indian Institute of Science Bangalore)
#2Preeti Sharma (IISc: Indian Institute of Science Bangalore)H-Index: 1
Last. Siddharth Jhunjhunwala (IISc: Indian Institute of Science Bangalore)H-Index: 25
view all 3 authors...
Particles injected intravenously are thought to be cleared by macrophages residing in the liver and spleen, but they also encounter circulating immune cells. It remains to be established if the circulating cells can take up particles while flowing and if the uptake capacity is similar under static and flow conditions. Here, we use an in vitro peristaltic pump setup that mimics pulsatile blood flow to determine if immune cells take up particles under constant fluidic flow. We use polystyrene part...
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