Intravenous immunoglobulins for the treatment of the hyper-inflammatory response in COVID-19. Another failure of immunomodulatory therapy?

Diphtheria toxin was discovered in 1880, and shortly after this the treatment of infectious diseases with the serum of convalescent patients was proposed for the first time [[1]Behring E. Kitasato S. Ueber das Zustandekommen der Diphtherie-Immunität bei Thieren.DMed Wschr. 1890; 16 (1113-4, 1145-8)Google Scholar]. Since then, a long chapter has been written in the history of medicine about the use of serum or plasma containing immunoglobulins...