Original paper
Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane
Abstract
The Sonic hedgehog (Shh) pathway controls embryonic development and tissue homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, firmly plasma membrane-associated Shh ligand is released from producing cells to signal to distant target cells and how the resistance-nodulation-division transporter Dispatched 1 (Disp, also known as Disp1) regulates this process. Here, we show that inactivation of Disp in...
Paper Details
Title
Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane
Published Date
Aug 19, 2021
Journal
Volume
135
Issue
5
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Notes
History