The human amniotic fluid stem cell secretome triggers intracellular Ca²⁺ oscillations, NF‐κB nuclear translocation and tube formation in human endothelial colony‐forming cells

Second trimester foetal human amniotic fluid-derived stem cells (hAFS) have been shown to possess remarkable cardioprotective paracrine potential in different preclinical models of myocardial injury and drug-induced cardiotoxicity. The hAFS secretome, namely the total soluble factors released by cells in their conditioned medium (hAFS-CM), can also strongly sustain in vivo angiogenesis in a murine model of acute myocardial infarction (MI) and...