Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk

Background and AimsAltered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn’s disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDRs) of CD patients is an independent risk factor for future CD development.MethodsWe measured host serum antibody response to 6 microbial antigens at enrollment (Prometheus enzyme-linked...