No effect of calcium and vitamin D intake on maternal blood pressure in a healthy pregnant population.

Published on Jul 7, 2021in European Journal of Obstetrics & Gynecology and Reproductive Biology1.868
· DOI :10.1016/J.EJOGRB.2021.07.005
Hannah Elizabeth Forde , Rachel K Crowley17
Estimated H-index: 17
(UCD: University College Dublin)
+ 5 AuthorsFionnuala M. McAuliffe57
Estimated H-index: 57
(UCD: University College Dublin)
Sources
Abstract
Abstract null null Objectives null Clinical studies have reported an inverse relationship between calcium and vitamin D intake and hypertensive disorders of pregnancy (HDP). The aim of this study was to investigate if there was an association between calcium/vitamin D intake, and vitamin D (25OHD) status, and maternal blood pressure (BP), during pregnancy and at 5-year follow-up. null null null Study Design null This was an observational study of 415 women who participated in the ROLO (Randomised cOntrolled trial of LOw glycaemic index diet for the prevention of recurrence of macrosomia) study. Maternal BP measurements were taken during each trimester and at 5-year follow-up. Calcium and vitamin D intake were determined at each trimester and 25OHD was measured in early and late pregnancy. null null null Results null Over two-thirds of the cohort were vitamin D sufficient (25OHD >30nmol/L) and had adequate calcium intake (>750mg/day). There was no correlation between calcium intake or vitamin D intake and maternal BP in trimester 1 to 3 or at 5-year follow-up. Vitamin D status at 13 weeks’ gestation negatively correlated with mean arterial pressure in trimester 1 (r = -0.152, p=0.044). There was no correlation however between 25OHD at 28 weeks’ gestation and BP at 28 or 34 weeks’ gestation or 25OHD and BP at 5-year follow-up. null null null Conclusions null In a healthy population of women with adequate calcium and vitamin D intake, no clinically significant correlation existed between calcium and vitamin D and maternal BP.
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Summary Background Maternal vitamin D deficiency has been associated with an increased risk for preeclampsia. Despite this, the current evidence regarding the efficacy of vitamin D supplementation in preventing preeclampsia is controversial. To assess the impact of vitamin D supplementation on the risk of preeclampsia, we performed a systematic review of the literature and a meta-analysis of the available randomized clinical trials (RCTs). Methods The primary outcome was preeclampsia. Subgroup a...
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There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin–angiotensin–aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone inc...
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