Rachel K Crowley
University College Dublin
Vitamin D and neurologyInternal medicineEndocrinologySurgeryResearch ethicsRandomized controlled trialBone remodelingIntensive care medicinePediatricsOsteoporosisX-linked hypophosphatemiaCraniopharyngiomaInsulin resistanceHypopituitarismPregnancyHypercalcaemiaContext (language use)In patientDiabetes mellitusMedicineBiologyGastroenterology
123Publications
17H-index
1,146Citations
Publications 123
Newest
#1Lydia O’ Sullivan (UCD: University College Dublin)
#2Laura Feeney (UCD: University College Dublin)
Last. Peter Doran (UCD: University College Dublin)H-Index: 34
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BACKGROUND The process of informed consent for enrolment to a clinical research study can be complex for both participants and research staff. Challenges include respecting the potential participant's autonomy and information needs while simultaneously providing adequate information to enable an informed decision. Qualitative research with small sample sizes has added to our understanding of these challenges. However, there is value in garnering the perspectives of research participants and staf...
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#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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Abstract null null Objectives null Clinical studies have reported an inverse relationship between calcium and vitamin D intake and hypertensive disorders of pregnancy (HDP). The aim of this study was to investigate if there was an association between calcium/vitamin D intake, and vitamin D (25OHD) status, and maternal blood pressure (BP), during pregnancy and at 5-year follow-up. null null null Study Design null This was an observational study of 415 women who participated in the ROLO (Randomise...
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#1Lydia O'Sullivan (UCD: University College Dublin)H-Index: 3
#2Ronan P. KilleenH-Index: 1
Last. Rachel K Crowley (UCD: University College Dublin)H-Index: 17
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BACKGROUND: Patients with COVID-19 may feel under pressure to participate in research during the pandemic. Safeguards to protect research participants include ethical guidelines [e.g. Declaration of Helsinki and good clinical practice (GCP)], legislation to protect participants' privacy, research ethics committees (RECs) and informed consent. The International Committee of Medical Journal Editors (ICMJE) advises researchers to document compliance with these safeguards. Adherence to publication g...
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#1Eleanor Coleman (National University of Ireland, Galway)
#2Lydia O'Sullivan (National University of Ireland, Galway)H-Index: 3
Last. Peter Doran (UCD: University College Dublin)H-Index: 34
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BACKGROUND In line with Good Clinical Practice and the Declaration of Helsinki, it is the investigator's responsibility to ensure that research participants are sufficiently informed, to enable the provision of informed consent. The Participant Information Leaflet/Informed Consent Form is key to facilitating this communication process. Although studies have indicated that clinical research Participant Information Leaflets/Informed Consent Forms are not optimal in terms of accessibility, there is...
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#1Geeta Hampson (Guy's Hospital)H-Index: 25
#2Mike StoneH-Index: 19
Last. Stuart H. Ralston (Western General Hospital)H-Index: 110
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It is acknowledged that the COVID-19 pandemic has caused profound disruption to the delivery of healthcare services globally. This has affected the management of many long-term conditions including osteoporosis as resources are diverted to cover urgent care. Osteoporosis is a public health concern worldwide and treatment is required for the prevention of further bone loss, deterioration of skeletal micro-architecture, and fragility fractures. This review provides information on how the COVID-19 ...
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Denosumab was approved for the treatment of postmenopausal osteoporosis in 2010, based on the FREEDOM study, which indicated a benefit in terms of increased bone mineral density and reduced risk of...
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#1Mark Kilbane (UCD: University College Dublin)H-Index: 13
#2Rachel K CrowleyH-Index: 17
Last. Patrick J TwomeyH-Index: 22
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Parathyroid hormone-related protein (PTHrP) can simulate most of the actions of parathyroid hormone (PTH) including increases in bone resorption and distal tubular calcium reabsorption and inhibition of proximal tubular phosphate transport.1 The low serum phosphate in parallel with low circulating PTH is consistent with PTHrP involvement in this case. Whether it can be causative for a serum calcium of 6.24 mmol/L however is a moot point. While the mechanism underlying the patient’s severe hyperc...
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