Daily Cannabis Use is Associated With Lower CNS Inflammation in People With HIV.

Published on Jul 1, 2021in Journal of The International Neuropsychological Society2.892
· DOI :10.1017/S1355617720001447
Ni Sun-Suslow3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Suzi Hong28
Estimated H-index: 28
(UCSD: University of California, San Diego)
Source
Abstract
OBJECTIVE Recent cannabis exposure has been associated with lower rates of neurocognitive impairment in people with HIV (PWH). Cannabis's anti-inflammatory properties may underlie this relationship by reducing chronic neuroinflammation in PWH. This study examined relations between cannabis use and inflammatory biomarkers in cerebrospinal fluid (CSF) and plasma, and cognitive correlates of these biomarkers within a community-based sample of PWH. METHODS 263 individuals were categorized into four groups: HIV- non-cannabis users (n = 65), HIV+ non-cannabis users (n = 105), HIV+ moderate cannabis users (n = 62), and HIV+ daily cannabis users (n = 31). Differences in pro-inflammatory biomarkers (IL-6, MCP-1/CCL2, IP-10/CXCL10, sCD14, sTNFR-II, TNF-α) by study group were determined by Kruskal-Wallis tests. Multivariable linear regressions examined relationships between biomarkers and seven cognitive domains, adjusting for age, sex/gender, race, education, and current CD4 count. RESULTS HIV+ daily cannabis users showed lower MCP-1 and IP-10 levels in CSF compared to HIV+ non-cannabis users (p = .015; p = .039) and were similar to HIV- non-cannabis users. Plasma biomarkers showed no differences by cannabis use. Among PWH, lower CSF MCP-1 and lower CSF IP-10 were associated with better learning performance (all ps < .05). CONCLUSIONS Current daily cannabis use was associated with lower levels of pro-inflammatory chemokines implicated in HIV pathogenesis and these chemokines were linked to the cognitive domain of learning which is commonly impaired in PWH. Cannabinoid-related reductions of MCP-1 and IP-10, if confirmed, suggest a role for medicinal cannabis in the mitigation of persistent inflammation and cognitive impacts of HIV.
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#2Nikolas Wada (Johns Hopkins University)H-Index: 15
Last. Kristine M. Erlandson (Anschutz Medical Campus)H-Index: 30
view all 9 authors...
Background: Chronic inflammation contributes to aging and organ dysfunction in the general population, and is a particularly important determinant of morbidity and mortality among people with HIV (...
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#1Ronald J. Ellis (UCSD: University of California, San Diego)H-Index: 90
#2Scott N. Peterson (UCSD: University of California, San Diego)H-Index: 1
Last. Mariana Cherner (UCSD: University of California, San Diego)H-Index: 36
view all 10 authors...
Objective To determine whether cannabis may reduce HIV-related persistent inflammation, we evaluated the relationship of cannabis use in people with HIV (PWH) to inflammatory cytokines in CSF and blood plasma. Methods We measured a panel of proinflammatory cytokines (interleukin [IL]-16, C-reactive protein [CRP], IL-6, interferon gamma-induced protein [IP]-10, soluble CD14, and soluble tumor necrosis factor receptor type II [sTNFRII]) in CSF and blood plasma in PWH and HIV− individuals who did o...
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#1Hannah A. Wang (UMB: University of Maryland, Baltimore)H-Index: 1
#2Huajun Liang (UMB: University of Maryland, Baltimore)H-Index: 14
Last. Linda ChangH-Index: 93
view all 5 authors...
Cognitive deficits and microstructural brain abnormalities are well documented in HIV-positive individuals (HIV+). This study evaluated whether chronic marijuana (MJ) use contributes to additional cognitive deficits or brain microstructural abnormalities that may reflect neuroinflammation or neuronal injury in HIV+. Using a 2 × 2 design, 44 HIV+ participants [23 minimal/no MJ users (HIV+), 21 chronic active MJ users (HIV + MJ)] were compared to 46 seronegative participants [24 minimal/no MJ user...
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#2Scott N. Peterson (DI: Discovery Institute)H-Index: 40
Last. Jenny Iudicello (UCSD: University of California, San Diego)H-Index: 2
view all 9 authors...
BACKGROUND: HIV infection leads to blood-brain barrier (BBB) dysfunction that does not resolve despite viral suppression on antiretroviral therapy and is associated with adverse clinical outcomes. In preclinical models, cannabis restores BBB integrity. METHODS: We studied people with HIV (PWH) and HIV- individuals who had used cannabis recently. We assessed two biomarkers of BBB permeability: the cerebrospinal fluid [CSF]-to-serum albumin ratio [CSAR], and CSF levels of soluble urokinase plasmin...
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Last. Cristian L. Achim (UCSD: University of California, San Diego)H-Index: 45
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HIV-associated neurocognitive disorder (HAND) is characterized by chronic immune activation. We aimed to identify biomarkers associated with HAND and to investigate their association with cognitive function and sex, in a homogenous cohort of HIV-infected (HIV+) young adults, parenterally infected during early childhood. One hundred forty-four HIV+ Romanian participants (51% women) without major confounders underwent standardized neurocognitive and medical evaluation in a cross-sectional study. I...
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#2Emily W Paolillo (UCSD: University of California, San Diego)H-Index: 12
Last. Igor Grant (UCSD: University of California, San Diego)H-Index: 131
view all 10 authors...
Background:Aging and HIV have adverse effects on the central nervous system, including increased inflammation and neural injury and confer risk of neurocognitive impairment (NCI). Previous research suggests the nonacute neurocognitive effects of cannabis in the general population are adverse or null
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#1Cecilia T Costiniuk (UQAM: Université du Québec à Montréal)H-Index: 1
Thanks to the success of modern antiretroviral therapy (ART), people living with HIV (PLWH) have life expectancies which approach that of persons in the general population. However, despite the ability of ART to suppress viral replication, PLWH have high levels of chronic systemic inflammation which
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#1Fernanda de Oliveira Feitosa de Castro (UFG: Universidade Federal de Goiás)H-Index: 1
#2Jacyelle Medeiros Silva (UFG: Universidade Federal de Goiás)H-Index: 1
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view all 17 authors...
Objectives:To evaluate the effects of cannabis and/or cocaine use on inflammatory, oxidative stress status and circulating monocyte subsets in HIV-infected individuals under antiretroviral therapy.Design:Soluble CD14 (sCD14), intestinal fatty acid-binding protein (IFABP), tumor necrosis factor-alpha
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#2Gretchen N. Neigh (VCU: Virginia Commonwealth University)H-Index: 28
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Purpose of Review Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for NCI.
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Last. Robert K. Heaton (UCSD: University of California, San Diego)H-Index: 127
view all 5 authors...
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