Terpenoids' anti-cancer effects: focus on autophagy.

Published on Jul 16, 2021in Apoptosis4.677
路 DOI :10.1007/S10495-021-01684-Y
Chirine El-Baba2
Estimated H-index: 2
(AUB: American University of Beirut),
Amro Baassiri2
Estimated H-index: 2
(AUB: American University of Beirut)
+ 4 AuthorsNadine Darwiche28
Estimated H-index: 28
(AUB: American University of Beirut)
Terpenoids are the largest class of natural products, most of which are derived from plants. Amongst their numerous biological properties, their anti-tumor effects are of interest for they are extremely diverse which include anti-proliferative, apoptotic, anti-angiogenic, and anti-metastatic activities. Recently, several in vitro and in vivo studies have been dedicated to understanding the 'terpenoid induced autophagy' phenomenon in cancer cells. Light has already been shed on the intricacy of apoptosis and autophagy relationship. This latter crosstalk is driven by the delicate balance between activating or silencing of certain proteins whereby the outcome is expressed via interrelated signaling pathways. In this review, we focus on nine of the most studied terpenoids and on their cell death and autophagic activity. These terpenoids are grouped in three classes: sesquiterpenoid (artemisinin, parthenolide), diterpenoids (oridonin, triptolide), and triterpenoids (alisol, betulinic acid, oleanolic acid, platycodin D, and ursolic acid). We have selected these nine terpenoids among others as they belong to the different major classes of terpenoids and our extensive search of the literature indicated that they were the most studied in terms of autophagy in cancer. These terpenoids alone demonstrate the complexity by which these secondary metabolites induce autophagy via complex signaling pathways such as MAPK/ERK/JNK, PI3K/AKT/mTOR, AMPK, NF-kB, and reactive oxygen species. Moreover, induction of autophagy can be either destructive or protective in tumor cells. Nevertheless, should this phenomenon be well understood, we ought to be able to exploit it to create novel therapies and design more effective regimens in the management and treatment of cancer.
馃摉 Papers frequently viewed together
6 Authors (Xuening Pang, ..., Zichao Li)
#1Samar Hosny (Mansoura University)H-Index: 1
#2Heba A. Sahyon (Kafrelsheikh University)H-Index: 6
Last. Amr Negm (King Faisal University)H-Index: 9
view all 4 authors...
Phytochemicals appeared as a rich source of efficient and safe agents against many diseases like cancer. Various herbal sources are rich in oleanolic acid (OA). The scope of this study was to assess the biochemical and molecular mechanisms implicated in the ameliorative potency of OA against DMBA-induced liver carcinogenesis. Forty-eight male albino mice were assigned randomly to five groups (eight mice each) as follows: control healthy group, olive oil group, OA group, DMBA group, and DMBA with...
#1Jie-Ping Fan (NCU: Nanchang University)H-Index: 16
#2Xiao-Hui Lai (NCU: Nanchang University)H-Index: 2
Last. Xianrui Liang (Zhejiang University of Technology)H-Index: 1
view all 7 authors...
Abstract Formation of ionic derivatives from drugs provided a simple tool to tune physical properties including water solubility and biological activity of the drugs. Oleanolic acid (OA) and ursolic acid (UA) are two ubiquitous isomeric triterpene phytochemicals with many pharmacological effects. But the poor water solubility greatly limits their clinical application. In order to improve the solubility of OA and UA, this research exploited a non-covalent synthetic approach to prepare a series of...
#6Tai Young Kim (Kyung Hee University)H-Index: 3
Targeting autophagy is a promising therapeutic approach in cancer therapy. Here, we screened 30 traditional herbal medicines to identify novel autophagy regulators and found that Platycodon聽grandiflorus (PG) and platycodin D (PD), a triterpenoid saponin from PG, inhibited autophagy in glioblastoma multiforme (GBM) cells. Mechanistically, PD prevented lysosomal degradation and the fusion between autophagosomes and lysosomes by inducing sequestration of free cholesterol in lysosomes. The autophagy...
#1Lu Tong (SHU: Shanghai University)H-Index: 1
#2Qunfei Zhao (SHU: Shanghai University)H-Index: 11
Last. Jun O. Liu (Johns Hopkins University)H-Index: 80
view all 10 authors...
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecul...
#1Qiudi Deng (Guangzhou Medical University)H-Index: 2
#2Xue-ping Lei (Guangzhou Medical University)H-Index: 6
Last. Xi-Yong Yu (Guangzhou Medical University)H-Index: 27
view all 14 authors...
Non-small cell lung cancer (NSCLC) is characterized by a high incidence of metastasis and poor survival. As epithelial-mesenchymal transition (EMT) is well recognized as a major factor initiating tumor metastasis, developing EMT inhibitor could be a feasible treatment for metastatic NSCLC. Recent studies show that triptolide isolated from Tripterygium wilfordii Hook F attenuated the migration and invasion of breast cancer, colon carcinoma, and ovarian cancer cells, and EMT played important roles...
#1Cheol Park (Dong-eui University)H-Index: 26
#2Jin-Woo JeongH-Index: 23
Last. Yung Hyun Choi (Dong-eui University)H-Index: 76
view all 10 authors...
Although previous studies have shown anti-cancer activity of betulinic acid (BA), a pentacyclic triterpenoid, against various cancer lines, the underlying molecular mechanisms are not well elucidat...
#1Yue ZhaoH-Index: 2
#2Weiwei XiaoH-Index: 1
Last. Hua JinH-Index: 25
view all 8 authors...
Oridonin has been shown to inhibit tumor cell growth and proliferation in vitro, while its optimum anti-tumor activity in vivo is limited due to the poor aqueous solubility and bioavailability. In this study, to improve the bioavailability, we developed a nanoparticle based drug delivery system to facilitate delivery of oridonin to breast tumor. Oridonin was encapsulated in biodegradable nanoparticles (NPs) based on poly-lactic-co-glycolic acid (PLGA) and polyethylene glycol (PEG) to form oridon...
#1Jing ZhouH-Index: 1
#2Yaocheng LiH-Index: 1
Last. Likun LiuH-Index: 1
view all 9 authors...
Purpose: Tumor blood vessels exhibit morphological and functional aberrancies. Its maturity and functionality are closely associated with colon cancer progression and therapeutic efficacy. The direct evidence proving whether oridonin (ORI) has vascular normalization promoting effect from which combination therapies will benefit is still lacking. Methods: We established a subcutaneous xenograft model of human colon cancer. The animals were divided into the Control and ORI-treated groups. Immunohi...
#1Min Ji Kwon (PNU: Pusan National University)H-Index: 2
#2Jeong Nam Kim (PNU: Pusan National University)H-Index: 3
Last. Byung Joo Kim (PNU: Pusan National University)H-Index: 31
view all 6 authors...
Alisol B 23鈥慳cetate聽(AB23A) is a natural triterpenoid isolated from Alismatis聽rhizoma, which exhibits a number of pharmacological activities. In the present study, AB23A鈥慽nduced anticancer efficacy was examined in AGS gastric cancer cells. Cell viability assay, cell cycle analysis, caspase activity assay, western blotting and reactive oxygen species聽(ROS) assay were used to investigate the anticancer effects of AB23A on AGS cells. AB23A reduced the viability of AGS cells, increased the sub鈥慓1 ce...
#1Yanying Zhong (NCU: Nanchang University)H-Index: 2
#2Fuyin Le (NCU: Nanchang University)H-Index: 1
Last. Buzhen Tan (NCU: Nanchang University)H-Index: 5
view all 9 authors...
Advanced and recurrent ovarian cancer has a poor prognosis and is frequently resistant to numerous therapeutics; thus, safe and effective drugs are needed to combat this disease. Previous studies have demonstrated that triptolide聽(TPL) exhibits anticancer and sensitization effects against cisplatin (DDP)鈥憆esistant ovarian cancer both in聽vitro and in聽vivo by inducing apoptosis; however, the involvement of autophagy induced by TPL in resistant ovarian carcinoma remains unclear. In the present stud...
Cited By0
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.