Apoptosis
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#1Xin Wang (Peking Union Medical College)H-Index: 4
#2Chunxiao Dong (Peking Union Medical College)H-Index: 1
Last. Weiyun Shi (Peking Union Medical College)H-Index: 16
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Fuchs endothelial corneal dystrophy (FECD) is one of the main causes for corneal endothelial blindness, which is characterized by the progressive decline of corneal endothelial cells. Poly (ADP-ribose) polymerase (PARP) was reported to be involved in cell death and apoptosis of several diseases. However, the role of PARP1 in the progression of FECD remains elusive. In the present study, we reported that UVA irradiation caused the corneal endothelial damage and corneal edema in mice, which was ac...
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#1Xiao Fu (SYU: Shaoyang University)
#2Mu Li (SYU: Shaoyang University)
Last. Masoud Najafi (Kermanshah University of Medical Sciences)H-Index: 32
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Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free radicals and induction of DNA damage. However, cancer cells can acquire some new properties to adapt to anti-cancer agents. An increase in the incidence of apoptosis, mitotic catastrophe, senescence, and necrosis is in favor of overcoming tumor resistance to therapy. Although an increase in the autophagy process may help the ...
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#1Paola Saccheri (University of Udine)H-Index: 4
#2Luciana Travan (University of Udine)H-Index: 10
This study highlights the historical contribution of Professor James Cormack by providing a Greek term that describes the process of programmed cell death. In 1972 the ancient Greek word "apoptosis" first appeared in the scientific literature. This short manuscript will examine the actual meaning of the term and its historical and phylological background. The word "apoptosis" contains a variety of semantic nuances that are perfectly suited to describe such a complex set of biological events as p...
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#1Shreya Das (BITS: Birla Institute of Technology and Science)
#2Nidhi Shukla (Case Western Reserve University)
Last. Richa Shrivastava (BITS: Birla Institute of Technology and Science)H-Index: 9
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The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are extensively focused areas of research in the context of cancer. Both the catabolic pathways play a significant role in maintaining cellular as well as organismal homeostasis. Autophagy facilitates this by degradation and elimination of misfolded proteins and damaged organelles, while apoptosis induces canonical cell death in response to various stimuli. Ideally, both autophagy and apoptosis have a role in tumor s...
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#1Wei Wang (CSU: Central South University)H-Index: 29
#2Mei-Feng Gu (CSU: Central South University)
Last. Liang Yang (CSU: Central South University)H-Index: 5
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Schwann cells (SCs) have important roles in supporting and repairing peripheral neurons, and thus have great potential for nerve injury treatment. Adipose tissue-derived stem cells (ADSCs) can be reliably induced to differentiate into SCs. However, the underlying molecular mechanisms are unclear. We explored the roles of MEG3/let-7a-5p/RBPJ axis in the differentiation into SCs from ADSCs. Primary ADSCs were induced to differentiate into SCs by appropriate reagents. ELISA, immunostaining, Western...
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#1Akvile Haeckel (Charité)H-Index: 6
#2Lena Ascher (BAM: Bundesanstalt für Materialforschung und -prüfung)H-Index: 1
Last. Eyk Schellenberger (Charité)H-Index: 22
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Annexin A5 (anxA5) is a marker for apoptosis, but has also therapeutic potential in cardiovascular diseases, cancer, and, due to apoptotic mimicry, against dangerous viruses, which is limited by the short blood circulation. An 864-amino-acid XTEN polypeptide was fused to anxA5. XTEN864-anxA5 was expressed in Escherichia coli and purified using XTEN as tag. XTEN864-anxA5 was coupled with DTPA and indium-111. After intravenous or subcutaneous injection of 111In-XTEN864-anxA5, mouse blood samples w...
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#1Chirine El-Baba (AUB: American University of Beirut)H-Index: 2
#2Amro Baassiri (AUB: American University of Beirut)H-Index: 2
Last. Nadine Darwiche (AUB: American University of Beirut)H-Index: 27
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Terpenoids are the largest class of natural products, most of which are derived from plants. Amongst their numerous biological properties, their anti-tumor effects are of interest for they are extremely diverse which include anti-proliferative, apoptotic, anti-angiogenic, and anti-metastatic activities. Recently, several in vitro and in vivo studies have been dedicated to understanding the 'terpenoid induced autophagy' phenomenon in cancer cells. Light has already been shed on the intricacy of a...
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#1Xiaofeng Dai (Jiangnan University)
#2Danjun Wang (Zhengzhou University)
Last. Jianying Zhang (Zhengzhou University)
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Cancer cells are disordered by nature and thus featured by higher internal redox level than healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain threshold, rendering therapeutic strategies relying on redox control a possible cancer management solution. Yet, various programmed cell death events have been consecutively discovered, complicating our understandings on their associations with redox imbalance and clinical implications especially therapeutic design. T...
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#1Zhentong Shen (NWAFU: Northwest A&F University)H-Index: 1
#2Ping Liu (Henan Agricultural University)H-Index: 1
Last. Chao Sun (NWAFU: Northwest A&F University)H-Index: 18
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As a nucleic acid demethylase, Fat and obesity associated gene (FTO) plays a vital role in modulating adipose metabolism. However, it is still unknown how FTO affects apoptosis in adipocytes. In this study, we found that overexpression of FTO inhibited the expression of pro-apoptosis factors Caspase-3, Caspase-9 and Bax and mitochondrial unfolded protein response (UPRmt) markers HSP60 and ClpP in vivo and in vitro. Particularly, overexpression of FTO inhibited mitochondria-dependent apoptosis in...
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#1Ting Sun (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lijiang Wei (Southern Medical University)H-Index: 2
Last. Ganghua Tang (Southern Medical University)H-Index: 14
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The purpose of this study was to employ novel tracers PET imaging approach to define the time course and intensity of myocardial repair after apoptosis and to correlate the imaging signal to immunohistochemical staining in myocardial infarction (MI). We designed novel αVβ3-targeted and radio-functionalized tracers for detection of apoptosis in H9C2 cells and myocardial tissue. MI rats were imaged with [18F]FDG, [18F]ANP-Cin or [18F]ANP-RGD2 using a small-animal PET/CT device. Rats were sacrifice...
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Top fields of study
Molecular biology
Apoptosis
Programmed cell death
Biology
Cell biology