Abstract 758: The clinical utility of BRCA1/2 pathogenic variants in breast cancer patient prognosis

Loss-of-function variants in the BRCA1 and BRCA2 genes cause hereditary breast cancer with high penetrance. The pathogenic BRCA1/2 variants are associated with high-grade tumors and early age at diagnosis, which both are associated with poor patient survival. However, it is unclear, whether the variants have prognostic value beyond the diagnosis age and tumor pathology. We present preliminary results from analyses of combined data from the CIMBA...