Anna Morra
Netherlands Cancer Institute
Genome-wide association studyInternal medicineArtOncologyCYP3A7HumanitiesHazard ratioRisk factors for breast cancerBody mass indexTumor SubtypeGenetic variantsBreast cancer specificPooled analysisLifestyle factorsReduced riskConfidence intervalProportional hazards modelRisk factorBreast cancerMedicineConfoundingEstrogen receptor
Publications 7
BACKGROUND Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. METHODS We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of Euro...
#1Anna MorraH-Index: 1
Last. Paul L. AuerH-Index: 48
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#1Taru A. MuranenH-Index: 33
#2Anna MorraH-Index: 1
Last. Bcac
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BACKGROUND It is not known if modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. METHODS We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer-specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) ...
#1Nichola Johnson (ICR: Institute of Cancer Research)H-Index: 46
#2Sarah Maguire ('QUB': Queen's University Belfast)H-Index: 10
Last. kConFab Investigators (ICR: Institute of Cancer Research)H-Index: 30
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BACKGROUND Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. METHODS We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To ...
#1Maria Escala-Garcia (NKI-AVL: Netherlands Cancer Institute)H-Index: 3
#2Anna Morra (NKI-AVL: Netherlands Cancer Institute)H-Index: 1
Last. Marjanka K. Schmidt (NKI-AVL: Netherlands Cancer Institute)H-Index: 67
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Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential residual confounding. Using a Mendelian randomisation (MR) approach, we aimed to examine the potential causal association between breast cancer-specific survival and nine established risk factors for breast cancer: alcohol consumption, body mass index, height, physical activity, mammogr...
6 CitationsSource
#1Anna MorraH-Index: 1
#2Audrey Y. JungH-Index: 12
Last. Jenny Chang-ClaudeH-Index: 124
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