Biodegradable T2-phage-like Janus nanoparticles for actively-targeted and chemo-photothermal synergistic therapy

Snowman-like Au-BNP (bovine serum albumin nanoparticle) Janus nanoparticles (AuBJNPs) are prepared through a facile adsorption-reduction seeds mediated growth method. The formation of the snowman-like structure is driven by a thermodynamic spontaneous process controlled by the reduction kinetics of AuCl4- ions. Thereafter, the AuBJNP nanoparticles have been selectively modified with thiol-aptamer AS1411 for specific tumor-targeting and NIR dye,...