Original paper
Structure–activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine
Abstract
Antimicrobial peptides (AMPs) are potential therapeutic agents against bacteria. We recently showed that a rationally designed AMP, termed Stripe, with an amphipathic distribution of native cationic and hydrophobic amino acids on its helical structure exhibited potent antimicrobial activity against Gram-positive and Gram-negative bacteria with negligible hemolytic activity and cytotoxicity. In this study, the structure-activity relationship of...
Paper Details
Title
Structure–activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine
Published Date
Jun 23, 2021
Journal
Volume
27
Issue
12
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Notes
History