Cardiac-induced liver deformation as a measure of liver stiffness using dynamic imaging without magnetization tagging—preclinical proof-of-concept, clinical translation, reproducibility and feasibility in patients with cirrhosis

MR elastography and magnetization-tagging use liver stiffness (LS) measurements to diagnose fibrosis but require physical drivers, specialist sequences and post-processing. Here we evaluate non-rigid registration of dynamic two-dimensional cine MRI images to measure cardiac-induced liver deformation (LD) as a measure of LS by (i) assessing preclinical proof-of-concept, (ii) clinical reproducibility and inter-reader variability, (iii) the effects...