Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis
Abstract
Punicalagin (PUN) is a common anti-inflammatory polyphenol. However, the function and mechanism of PUN in osteoarthritis remains unknown. Chondrocytes were isolated from rats, and confirmed by toluidine blue staining and immunofluorescence. Chondrocytes were challenged by lipopolysaccharide (LPS), and rat osteoarthritis model was established by Hulth method. The secretion of inflammatory factors, cell viability and apoptosis were tested via...
Paper Details
Title
Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis
Published Date
Nov 1, 2021
Journal
Volume
152
Pages
116070 - 116070
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