Papers 10000
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#1S. Mahsa Sadeghian (NU: Northeastern University)H-Index: 1
#2Frederic D. Shapiro (NU: Northeastern University)
Last. Sandra J. Shefelbine (NU: Northeastern University)H-Index: 36
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Abstract null null Mechanical loading is a crucial factor in joint and bone development. Using a computational model, we investigated the role of mechanics on cartilage growth rate, ossification of the secondary center, formation of the growth plate, and overall bone shape. A computational algorithm was developed and implemented into finite element models to simulate the endochondral ossification for symmetric and asymmetric motion in a generic diarthrodial joint. Under asymmetric loading condit...
#1Shubo Wang (UD: University of Delaware)
#2Shaopeng Pei (UD: University of Delaware)H-Index: 7
Last. Liyun Wang (UD: University of Delaware)H-Index: 30
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Abstract null null Osteolytic bone lesions, which develop in many metastatic breast cancer patients, impair bone integrity and lead to adverse skeletal related events that are difficult to treat and sometimes fatal. Moderate mechanical loading has been shown to suppress osteolysis in young mice with breast cancer. In this study, we aimed to investigate the dose-dependent effects of mechanical loading on protecting the integrity of adult skeletons with breast cancer. Localized tibial loading and ...
#1Haipeng Cen (Beihang University)H-Index: 1
#2Yan Yao (Beihang University)
Last. He Gong (Beihang University)H-Index: 2
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Abstract null null Background null Bone remodeling in the elderly is no longer balanced. As a result, the morphologies and mechanical properties of bone at different scales will change. These changes would affect the mechanical responses of bone, which might exacerbate the imbalance of bone remodeling and even cause age-related bone diseases. null null null Methods null Considering those changes, multiscale finite element (FE) models of bone in the young and the elderly were developed that inclu...
#1Michiel Herteleer (Katholieke Universiteit Leuven)H-Index: 5
#2Marian Dejaeger (Katholieke Universiteit Leuven)H-Index: 4
Last. Michaël R. Laurent (Katholieke Universiteit Leuven)H-Index: 26
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Abstract null null Introduction null Fractures of the pelvis and acetabulum are associated with osteoporosis, and their incidence is rising in older adults. In the last decade an increasing number of these fractures are being operated in older patients in certain regions. The goal of this study was to describe the incidence of pelvic and acetabular fractures in Belgium between 1988 and 2018. null null null Materials & Methods null This retrospective, nationwide, population-based study was conduc...
#1Sophia N. Ziemian (Cornell University)H-Index: 2
#2Olufunmilayo O. Ayobami (Cornell University)
Last. Marjolein C. H. van der Meulen (HSS: Hospital for Special Surgery)H-Index: 40
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Abstract null null Objective null Reduced subchondral bone mass and increased remodeling are associated with early stage OA. However, the direct effect of low subchondral bone mass on the risk and severity of OA development is unclear. We sought to determine the role of low bone mass resulting from a bone-specific loss of estrogen signaling in load-induced OA development using female osteoblast-specific estrogen receptor-alpha knockout (pOC-ERαKO) mice. null null null Methods null Osteoarthritis...
#1John L. Fowlkes (UK: University of Kentucky)H-Index: 37
#2Kathryn M. Thrailkill (UK: University of Kentucky)H-Index: 36
Last. R. Clay Bunn (UK: University of Kentucky)H-Index: 16
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The RASopathies comprise an ever-growing number of clinical syndromes resulting from germline mutations in components of the RAS/MAPK signaling pathway. While multiple organs and tissues may be affected by these mutations, this review will focus on how these mutations specifically impact the musculoskeletal system. Herein, we review the genetics and musculoskeletal phenotypes of these syndromes in humans. We discuss how mutations in the RASopathy syndromes have been studied in translational mous...
#1Ioanna V. Papathanasiou (UTH: University of Thessaly)H-Index: 20
Last. Aspasia Tsezou (UTH: University of Thessaly)H-Index: 35
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Abstract null null Cholesterol homeostasis plays a significant role in skeletal development and the dysregulation of cholesterol-related mechanism has been shown to be involved in the development of cartilage diseases including osteoarthritis (OA). Epidemiological studies have shown an association between elevated serum cholesterol levels and OA. Furthermore, abnormal lipid accumulation in chondrocytes as a result of abnormal regulation of cholesterol homeostasis has been demonstrated to be invo...
#1Karl J. Lewis (CCNY: City College of New York)H-Index: 4
#2Pamela Cabahug-Zuckerman (CCNY: City College of New York)H-Index: 5
Last. Robert J. Majeska (CCNY: City College of New York)H-Index: 17
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Abstract null null Microstructural adaptation of bone in response to mechanical stimuli is diminished with estrogen deprivation. Here we tested in vivo whether ovariectomy (OVX) alters the acute response of osteocytes, the principal mechanosensory cells of bone, to mechanical loading in mice. We also used super resolution microscopy (Structured Illumination microscopy or SIM) in conjunction with immunohistochemistry to assess changes in the number and organization of “osteocyte mechanosomes” - c...
#1FeiFei Liu (Zhengzhou University)
#2Hao Yang (Zhengzhou University)
Last. Qicai Han (Zhengzhou University)H-Index: 6
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Abstract null null Background null Punicalagin (PUN) is a common anti-inflammatory polyphenol. However, the function and mechanism of PUN in osteoarthritis remains unknown. null null null Methods null Chondrocytes were isolated from rats, and confirmed by toluidine blue staining and immunofluorescence. Chondrocytes were challenged by lipopolysaccharide (LPS), and rat osteoarthritis model was established by Hulth method. The secretion of inflammatory factors, cell viability and apoptosis were tes...
#1Tania L. Jones (RVI: Royal Victoria Infirmary)
#2Mohammed S. Esa (RVI: Royal Victoria Infirmary)
Last. Fraser Birrell (RVI: Royal Victoria Infirmary)H-Index: 30
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Abstract null null Circulating microRNAs (c-miRs) show promise as biomarkers. This systematic review explores their potential association with age-related fracture/osteoporosis (OP), osteoarthritis (OA) and sarcopenia (SP), as well as cross-disease association. Most overlap occurred between OA and OP, suggesting potentially shared microRNA activity. There was little agreement in results across studies. Few reported receiver operating characteristic analysis (ROC) and many identified significant ...
Top fields of study
Bone remodeling
Bone mineral