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#1Bin He (CQMU: Chongqing Medical University)H-Index: 9
#2Jinqiu Zhao (CQMU: Chongqing Medical University)H-Index: 4
Last. Wei Huang (CQMU: Chongqing Medical University)H-Index: 22
view all 7 authors...
Abstract null null Circulating adiponectin has some association with the risk of osteoporosis and cancers, but their causal relationships remains elusive. Mendelian randomization (MR) study was used to explore the causal roles of circulating adiponectin in osteoporosis and cancers by using genome-wide association studies (GWASs) associated with circulating adiponectin, osteoporosis and cancers. Fifteen single nucleotide polymorphisms (SNPs) were used as instrumental variables for circulating adi...
#1Peihong Su (NPU: Northwestern Polytechnical University)H-Index: 12
#2Ye Tian (NPU: Northwestern Polytechnical University)H-Index: 11
Last. Yu Li (NPU: Northwestern Polytechnical University)H-Index: 7
view all 11 authors...
Abstract null null Rationale null The migration of osteoblastic cells to bone formation surface is an essential step for bone development and growth. However, whether the migration capacity of osteoblastic cells is compromised during osteoporosis occurrence and how it contributes to bone formation reduction remain unexplored so far. In this work, we found, as a positive regulator of cell migration, microtubule actin crosslinking factor 1 (MACF1) enhanced osteoblastic cells migration. We also exa...
#1Ingmar Fleps (ETH Zurich: ETH Zurich)H-Index: 9
#2Halldór Pálsson (University of Iceland)H-Index: 19
Last. Vilmundur GudnasonH-Index: 112
view all 12 authors...
Abstract null null Hip fractures associated with a high economic burden, loss of independence, and a high rate of post-fracture mortality, are a major health concern for modern societies. Areal bone mineral density is the current clinical metric of choice when assessing an individual's future risk of fracture. However, this metric has been shown to lack sensitivity and specificity in the targeted selection of individuals for preventive interventions. Although femoral strength derived from comput...
#1Ji Sup Hwang (SNUBH: Seoul National University Bundang Hospital)
#2Sanguk Lee (SNUBH: Seoul National University Bundang Hospital)
Last. Hyun Sik Gong (SNUBH: Seoul National University Bundang Hospital)H-Index: 22
view all 3 authors...
Abstract null null Introduction null Bone turnover markers (BTM) are used in evaluating patients' response to anti-resorptive agents (ARA). Fracture and its healing process, however, can influence the measurements, which might make their interpretation difficult in patients with a recent fracture. We aimed to evaluate the effect of oral ARA on changes in BTM levels in patients with a recent distal radius fracture (DRF). null null null Methods null In 143 women who had a new DRF and then received...
#1Bohao Ning (Polytechnique Montréal)
#2Irène LondonoH-Index: 15
Last. Isabelle Villemure (Polytechnique Montréal)H-Index: 20
view all 4 authors...
Bone growth is an essential part of skeletal development during childhood and puberty. Accurately characterizing longitudinal bone growth helps to better understand the determining factors of peak bone mass, which has impacts on bone quality later in life. Animal models were largely used to study longitudinal bone growth. However, the commonly used histology-based method is destructive and unable to follow up the growth curve of live animals in longitudinal experiments. In this study, we validat...
#1Alex Ireland (MMU: Manchester Metropolitan University)H-Index: 17
#2Amy Riddell (SGUL: St George's, University of London)
Last. Kate A Ward (University of Southampton)H-Index: 34
view all 6 authors...
Abstract null null Neurofibromatosis type 1 (NF1) is associated with lower bone mass and increased risk of fracture. Children with NF1 display faltering growth from mid-childhood. However, to date tibia bone development in children with NF1 across childhood and the role of body size have not been explored. null Therefore, we recruited 24 children with NF1 (12 girls, mean age 8.2 ± 1.1y) and 104 children without NF1 (52 girls, mean age 11 ± 1.7y). Tibia and fibula bone characteristics were assess...
#1Mitsuru Doi (Nagasaki University)H-Index: 1
#2Ko Chiba (Nagasaki University)H-Index: 11
Last. Makoto Osaki (Nagasaki University)H-Index: 24
view all 9 authors...
Abstract null null Objective null The primary purpose of this cross-sectional study was to investigate the characteristics of age-related changes in bone microstructure on high-resolution peripheral quantitative computed tomography (HR-pQCT), areal bone mineral density (aBMD) on dual-energy X-ray absorptiometry (DXA), and bone-related biochemical markers in men. The secondary purpose of this study was to examine how bone microstructure is related to aBMD and biochemical markers. null null null M...
#1Ehud Even-Or (HUJI: Hebrew University of Jerusalem)H-Index: 6
#2Gali Schiesel (HUJI: Hebrew University of Jerusalem)
Last. Polina Stepensky (HUJI: Hebrew University of Jerusalem)H-Index: 29
view all 8 authors...
Abstract null null Malignant infantile osteopetrosis (MIOP) is the autosomal recessive, severe form of osteopetrosis. This rare genetic syndrome usually presents soon after birth and is often fatal if left untreated. Early diagnosis is key for proper management but clinical presentation is diverse, and oftentimes diagnosis may be challenging. In this study, we retrospectively collected data of genetic mutations and phenotypic characteristics at the initial presentation of 81 MIOP patients and an...
#1N. Crabtree (UHB: University Hospitals Birmingham NHS Foundation Trust)H-Index: 1
#2H. Roper (University of Birmingham)
Last. N.J. Shaw (UHB: University Hospitals Birmingham NHS Foundation Trust)
view all 3 authors...
Glucocorticoids are currently used to improve muscle strength and prolong ambulation in boys with DMD although the effect on bone health is still unclear. The aim of this study was to compare bone strength in healthy children and boys with DMD and investigate the interaction between diminished muscle function, loss of ambulation and high dose oral steroids, over a two year time frame. Fifty children were studied, 14 healthy boys (HB), 13 boys with DMD who remained ambulant (DMD-RA) and 23 boys w...
#1Akane Inoue (Kyushu University)
#2Tamotsu Kiyoshima (Kyushu University)H-Index: 26
Last. Koji Okabe (Fukuoka Dental College)H-Index: 23
view all 15 authors...
Amelogenesis consists of secretory, transition, maturation, and post-maturation stages, and the morphological changes of ameloblasts at each stage are closely related to their function. p130 Crk-associated substrate (Cas) is a scaffold protein that modulates essential cellular processes, including cell adhesion, cytoskeletal changes, and polarization. The expression of p130Cas was observed from the secretory stage to the maturation stage in ameloblasts. Epithelial cell-specific p130Cas-deficient...
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