Social disruption–induced stress pre-exposure aggravates, while the presence of conspecifics diminishes, acetic acid–induced writhing

This study was undertaken to assess the modulating effects of (1) pre-exposure to repeated social disruption and (2) group testing on writhing associated with visceral pain induced by intraperitoneal administration of acetic acid. Six consecutive days of social disruption were used to prime for stress, while group testing referred to 3 mouse cage-mates receiving the acetic acid–induced writhing test as a group. Social disruption–induced...