Structure and transport mechanism of P5B-ATPases
Abstract
In human cells, P5B-ATPases execute the active export of physiologically important polyamines such as spermine from lysosomes to the cytosol, a function linked to a palette of disorders. Yet, the overall shape of P5B-ATPases and the mechanisms of polyamine recognition, uptake and transport remain elusive. Here we describe a series of cryo-electron microscopy structures of a yeast homolog of human ATP13A2-5, Ypk9, determined at resolutions...
Paper Details
Title
Structure and transport mechanism of P5B-ATPases
Published Date
Jun 25, 2021
Journal
Volume
12
Issue
1
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