Genetic drivers of m6A methylation in human brain, lung, heart and muscle
Abstract
The most prevalent post-transcriptional mRNA modification, N6-methyladenosine (m6A), plays diverse RNA-regulatory roles, but its genetic control in human tissues remains uncharted. Here we report 129 transcriptome-wide m6A profiles, covering 91 individuals and 4 tissues (brain, lung, muscle and heart) from GTEx/eGTEx. We integrate these with interindividual genetic and expression variation, revealing 8,843 tissue-specific and 469 tissue-shared...
Paper Details
Title
Genetic drivers of m6A methylation in human brain, lung, heart and muscle
Published Date
Jul 1, 2021
Journal
Volume
53
Issue
8
Pages
1156 - 1165
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