Original paper
Epithelial cell plasticity drives endoderm formation during gastrulation
Abstract
It is generally accepted that epiblast cells ingress into the primitive streak by epithelial-to-mesenchymal transition (EMT) to give rise to the mesoderm; however, it is less clear how the endoderm acquires an epithelial fate. Here, we used embryonic stem cell and mouse embryo knock-in reporter systems to combine time-resolved lineage labelling with high-resolution single-cell transcriptomics. This allowed us to resolve the morphogenetic...
Paper Details
Title
Epithelial cell plasticity drives endoderm formation during gastrulation
Published Date
Jun 24, 2021
Journal
Volume
23
Issue
7
Pages
692 - 703
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Notes
History