Fish oil supplementation alters emotion‐generated corticolimbic functional connectivity in depressed adolescents at high‐risk for bipolar I disorder: A 12‐week placebo‐controlled fMRI trial

Objective To evaluate the effects of fish oil (FO), a source of the omega‐3 polyunsaturated fatty acids ( n ‐3 PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on emotion‐generated corticolimbic functional connectivity in depressed youth at high risk for developing bipolar I disorder. Methods Thirty‐nine antidepressant‐free youth with a current depressive disorder diagnosis and a biological parent with bipolar I disorder were...