Magnoliaceae

Biology

Magnolia officinalis

Biochemistry

Botany

Traditional Chinese medicine

Ginkgo biloba

Stereochemistry

Polymer

Alternative medicine

Organic chemistry

In vitro

Circular dichroism

IC50

Medicine

Chemistry

Monomer

Moiety

Pathology

Chinese Journal of Natural Medicines

Six new oligomeric neolignans including two trimeric neolignans (1 and 2) and four dimeric neolignans (3-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined based on HR-ESIMS and NMR data, as well as electronic circular dichroism (ECD) calculations. Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety, which is an unprecedented type of linkage between monomers. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1 and 3 showed significantly inhibitory activities with IC50 values of 6.04 and 3.26 μmol·L-1, respectively.

New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba