The effect of some acrylic polymers on dissolution of celecoxib solid dispersion formulations

The purpose of the present study was firstly to identify the effectiveness of Eudragit® polymers (Eudragit® RL, RS, L100-55, L100, S100 and E100) in inhibition of celecoxib precipitation from buffer solutions (pH = 6.8). Furthermore, the influence of Eudragit® polymers on non-sink dissolution behavior of celecoxib from solid dispersions was investigated.Solid dispersions were prepared by the rotary evaporation method. In vitro dissolution...