A small molecule IAP inhibitor sensitises medulloblastoma cells to radiation therapy and cytotoxic chemotherapy in vitro and in vivo

Novel strategies for treating medulloblastoma are urgently needed. null Despite intensive treatment one quarter of patients ultimately succumb to their disease. null Radiation therapy is a critical component of current treatment strategies but often results in devastating long-term effects, particularly in younger patients. null Strategies to sensitise medulloblastoma cells to the effects of radiation therapy have been proposed as a mechanism to...